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Dialysis For ESRD

Dialysis is the process of artificially removing wastes from the blood.  This becomes necessary when the kidneys fail and are no longer able to function efficiently.  When there is complete and irreversible kidney failure, known as end stage renal disease (ESRD), dialysis helps to clean the blood and avoid the accumulation of toxins in the body.

End stage renal disease (ESRD) is the most advanced and severe form of kidney disease.  At this stage, the kidneys stop working completely, or function below 10% of their capacity.

If the kidneys fail completely, outside of a kidney transplant, the primary treatment of kidney failure includes hemodialysis (haemodialysis), hemofiltration (haemofiltration), and peritoneal dialysis. These treatments help to artificially remove toxins and other wastes from the blood, since the kidneys are no longer able to do so.


Hemodialysis (commonly referred to as dialysis) is a kidney failure treatment that is administered in both acute and chronic renal failure cases.

Dialysis involves circulating the blood outside of the body through an extra corporeal circuit (ECC) or dialysis-circuit.  This circuit is made up of plastic tubing, a filter known as a dialyzer (or artificial kidney), and a dialysis machine.

The machine monitors and maintains blood flow and administers dialysate.  Dialysate (dialysis fluid) is a sterile chemical solution that is used to draw waste products out of the blood.  Fluid removal takes place after the blood leaves the body and passes through the extra corporeal circuit (ECC) and the dialyzer (filter).


Blood is pumped from the radial artery (in the arm) through the machine, where it is filtered. Harmful wastes and extra salt and fluids are removed.  The clean blood is then returned to the body by way of a vein in the arm.

The duration of one course of dialysis (called a "run") may last for three to four hours, depending on the dialyzer used and the condition of the patient.  Hemodialysis patients usually require three sessions per week.  During a "run", waste products and excess water are carried from the bloodstream out of the body. At the same time, electrolytes and other chemicals are added to the blood.  The purified and chemically balanced blood is then returned to the body.


Also, patients are typically given a hormone called erythropoietin (eh-RITH-ro-POY-eh-tin), by injection, to compensate for the lack of this vital hormone, which is normally produced by the kidneys.  Erythropoietin (EPO) is a hormone produced by healthy kidneys. It stimulates the bone marrow to produce red blood cells.


Hemofiltration is another kidney failure treatment that helps to artificially remove waste and excess fluids from the blood.  It is known as continuous renal replacement therapy (CRRT).  This procedure is a slow continuous blood filtration therapy, used mainly to control acute kidney failure, in critically ill patients.

These patients are typically very sick and may have heart problems or circulatory problems.  Consequently, they cannot handle the rapid filtration rates of hemodialysis.  They frequently need antibiotics, nutrition, and other fluids administered through a vein, to treat their primary condition.  Since hemofiltration is a slow continuous process, it is easier to give the required fluids to patients with kidney failure, without the risk of fluid overdose.

Hemofiltration also uses a dialysis circuit (ECC).  A hollow fiber filter (hemofilter) is used instead of a dialyzer.  This is responsible for removing excess fluids and toxins from the blood.  Instead of a dialysis machine, hemofiltration uses a blood pump, which causes the blood to circulate through the ECC.

The volume of blood that flows through the ECC is much lower than in hemodialysis.  The rates of filtration are slower and gentler on the circulatory system.  This kidney failure treatment is generally used until kidney failure is reversed, in patients with acute kidney failure.


This treatment is generally administered to patients with chronic kidney failure.  It can also be uses by patients with acute kidney failure, once they are stable and not in immediate crisis.

Peritoneal Dialysis uses the patient's peritoneum as a blood filter.  The peritoneum is the membrane (thin flexible skin-like tissue) that lines the abdominal cavity.  A flexible tube-like instrument (called a catheter) is surgically inserted into the patient's abdomen.

During this unique procedure, the catheter is used to fill the abdominal cavity with dialysate.  Dialysate is a sterile chemical solution that is used to draw waste products out of the blood.

Waste products and excess fluids move from the patient's blood into the dialysate.  After a period of time the waste-filled dialysate is drained from the patient's abdomen, and replaced with clean dialysate.

Even in the best situation, adjusting to the effects of kidney failure can be difficult.  Dialysis takes up a lot of time and may leave the patient feeling weak.  It may require some changes at home and at work... schedules may have to be changed and some activities and responsibilities may have to be given up.  Additionally, dialysis and other kidney failure treatments can be expensive and become a financial burden to the patient and their relatives.  The many challenges presented, can be overwhelming and difficult to adjust to.

For persons who may be suffering with end stage renal disease (ESRD) and may have to undergo dialysis, do not despair.  Do your best to keep a positive outlook.  Even if you have been waiting for a donated kidney for a long time, do not lose hope.  If you begin to feel depressed, talk with you social worker, doctor, relatives, friends and most importantly, GOD.

Manage your diet well!  Eating the right foods can help to improve your dialysis and your health.  Talk with your dietitian to help you plan your meals and follow his/ her advice closely.  Stay active and positive, and do all in your power to overcome the many challenges of kidney failure.

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